Cloxacillin is a semi-synthetic penicillin and antibiotic drug. The interaction of sodium salt of cloxacillin with Zn2 and Pb2 ions were studied using cyclic voltammetric and FT-IR techniques. Cyclic voltammogram of Zn2 and Pb2 ions showed characteristic peaks attributed to reduction/ oxidation through crossover, due to the process of nucleation on the surface of working electrode In presence of sodium salt of cloxacillin, the crossover and reduction peak shifted to negative direction where as oxidation towards more positive potential. These results confirmed that the oxidation/reduction of metal ions become more difficult because of formation of some sort of complexes with these molecules. FT-IR spectra showed the formation of cloxacillin-metal complex through the amide, �Ÿ-lactam carbonyls and a carboxylate group.
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